Casein glycomacropeptide

Casein glycomacropeptide

Casein glycomacropeptide, a natural choice for PKU nutrition

Lacprodan® CGMP-20 is a highly purified casein glycomacropeptide (CGMP) product with a very low level of the amino acid phenylalanine. Due to this characteristic, Lacprodan® CGMP-20 is an ideal protein source for phenylketonuria (PKU), a rare genetic condition in which patients are not able to metabolize phenylalanine efficiently1.

The current PKU diet consists of a low protein diet and supplementation with free amino acids to limit the patient’s intake of phenylalanine. Partial substitution of free amino acids with Lacprodan® CGMP-20 provides additional benefits, such as2:

  • Improved compliance due to better palatability
  • Potentially improved gut health

Due to its very high content of large neutral amino acids, including threonine and isoleucine, which compete for uptake into the brain with phenylalanine2, CGMP can help to avoid accumulation of toxic levels of phenylalanine in the brain of patients with PKU1. Moreover, due to its low content of phenylalanine and tyrosine, CGMP is also a suitable dietary supplement for patients with tyrosinemia and alkaptonuria.

Product range

  • Lacprodan®CGMP-20 is a casein glycomacropeptide of high purity and a very low level of phenylalanine. It is a versatile, palatable ingredient that can be used in different types of medical nutrition applications such as UHT drinks, bars and powders.


1.Daly, A., et al., Glycomacropeptide in PKU-Does It Live Up to Its Potential? Nutrients, 2022. 14(4).
2.Larsen, E.R., et al., Dietary supplementation with casein glycomacropeptide, leucine and tryptophan reduces plasma amino acid levels in men. Acta Neuropsychiatr, 2021: p. 1-8.




Click to get in touch