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Osteopontin

Osteopontin

Osteopontin

Osteopontin - supporting immune maturation

The whey protein osteopontin has been identified in high amounts in human milk, whereas only small quantities are present in bovine milk. As a consequence, infant formulas have a significantly lower content of osteopontin than human breast milk, which may impact areas like immune development.

Osteopontin is a heavily phosphorylated, acidic glycoprotein with strong calcium-binding properties. At Arla Foods Ingredients we can provide you with min. 95% pure form of osteopontin, Lacprodan® OPN-10, which was the first osteopontin product on the market.

The research in osteopotin

Preliminary research suggests that osteopontin plays a part in the development of infant immune functions, promoting maturation of the immune system and protecting against pathogenic infections. The addition of Lacprodan® OPN-10 to an infant formula may encourage similar immune modulation in formula-fed infants compared to breastfed infants. It therefore could be the missing link in infant formulas to deliver immune protection similar to human milk.

Benefits associated with osteopontin

  • Shifts PBMC gene expression closer to breastfed profiles
  • Natural role in infant immune development
  • Delivers immune protection similar to human milk
  • Mimics human milk of OPN levels
  • Reduces days of fever

At Arla Foods Ingredients, we hold several patents for production and application of osteopontin.

 

Leading image: Artistic interpretation of osteopontin.

Arla Foods Ingredients supports the WHO recommendation for exclusive breastfeeding for the first six months of an infant’s life and continued breastfeeding up to the age of two or beyond in combination with nutritionally appropriate complementary foods.

Arla Foods Ingredients supports the WHO recommendation for exclusive breastfeeding for the first six months of an infant’s life and continued breastfeeding up to the age of two or beyond in combination with nutritionally appropriate complementary foods.

Highlighted Arla Foods Ingredients’ collaboration studies

Osteopontin in human milk and infant formula affects infant plasma ostepontin concentrations

https://www.ncbi.nlm.nih.gov/pubmed/30636771
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Effects of osteopontin-enriched formula on lymphocyte subsets in the first 6 months of life: a randomized controlled trial

https://www.ncbi.nlm.nih.gov/pubmed/28355198
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Growth, nutrition, and cytokine response of breast-fed infants and infants fed formula with added bovine osteopontin

https://www.ncbi.nlm.nih.gov/pubmed/26465791
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Pre-clinical in vitro and in vivo safety evaluation of bovine whey derived osteopontin, Lacprodan® OPN-10

https://www.ncbi.nlm.nih.gov/pubmed/25072164
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Suppression of tumor growth by orally administered osteopontin is accompanied by alterations in tumour blood vessels

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950862/
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Bovine osteopontin modifies the intestinal transcriptome of formula-fed infant rhesus monkeys to be more similar to those that were breastfed

https://www.ncbi.nlm.nih.gov/pubmed/25320184
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Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising resistance in preterm pig

https://www.ncbi.nlm.nih.gov/pubmed/20723273
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Effects of Bovine alpha-lactalbumin and Casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants

https://www.ncbi.nlm.nih.gov/pubmed/17130747
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Osteopontin levels in human milk vary across countries and within lactation period: Data from a multicenter study

https://pubmed.ncbi.nlm.nih.gov/29668569/
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In vitro digestion of novel milk protein ingredients for use in infant formulas: Research on biological functions

https://www.sciencedirect.com/science/article/pii/S0924224404000068
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