Casein glycomacropeptide for medical nutrition
Lacprodan® CGMP-20 is a highly purified casein glycomacropeptide product with a very low level of the amino acid phenylalanine. Lacprodan® CGMP-20 furthermore contains a very high level of large neutral amino acids, such as threonine and isoleucine, which compete for uptake into the brain with phenylalanine.
Lacprodan® CGMP-20 is therefore an outstanding protein source for people with phenylketonuria (PKU) since these patients are not able to metabolize phenylalanine efficiently.
Benefits for patients with phenylketonuria (PKU)
The current PKU diet consists of a low protein diet and free amino acids supplements in order to limit the patients intake of phenylalanine. Partly substitution of free amino acids with Lacprodan® CGMP-20 provides additional benefits to the patient, such as:
- Improved compliance due to a better palatability
- Improved satiety
- Potentially improved bone health
- Potentially improved gut health
Due to its low content of aromatic amino acids, casein glycomacropeptide is also a suitable dietary supplement for patients with hepatic diseases and Tyrosinemia.
Highly concentrated dairy source for threonine
The Lacprodan® CGMP-10 ingredient contains about 18% threonine – a level about three times higher than that of a standard whey protein concentrate. This makes it a highly concentrated dairy source of threonine.
Threonine constitutes about 22% of the peptide core. Thus, administration of a dose of threonine could potentially have a beneficial effect upon gut health by ensuring enough threonine is available for mucin synthesis.
Lacprodan® may reduce bowel disease symptoms
Lacprodan® CGMP may also help reduce inflammatory bowel disease (IBD) symptoms. Animal studies and a human pilot study in IBD patients suffering active distal ulcerative colitis have indicated that nutritional supplementation with Lacprodan® CGMP is safe, well tolerated and may help reduce the disease activity.
- Lacprodan® CGMP-10: Casein glycomacropeptide with minimum 75% CGMP and a high content of sialic acid and above 83% protein concentrate approx. dry matter
- Lacprodan® CGMP-20: Casein glycomacropeptide with minimum 95% CGMP and a very low level of phenylalanine and above 78% protein concentrate approx. dry matter