Scientific documentation is central to Arla Foods Ingredients’ Early life nutrition ingredient portfolio. We are committed to deliver safety and efficacy evidence of our ingredients for the infant formula industry by providing our customers highly developed and targeted pre-clinical and clinical evidence that can be integrated into their final product documentation.
Over the years, we’ve built a reputation for solid, evidence-based clinical research in the industry. This work is carried out in close collaboration with leading research partners to provide a solid understanding of the role and mechanism of our ingredients developed for early life nutrition.
Close attention to this aspect is an unwavering principle that has guided our development efforts and documentation investments for decades. At Arla Foods Ingredients, the Early life nutrition department is on a journey to discover and deliver science based ingredients that support early life nutrition.
Arla Foods Ingredients’ partnerships applies to market insights as well as our sales and marketing experts can contribute valuable industry and consumer insights to support product positioning efforts and accelerate time-to-market.
Science & Insights
Highlighted Arla Foods Ingredients’ collaboration studies
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Feeding infants formula with probiotics or milk fat globule membrane: a double-blind, randomized controlled trial
https://www.frontiersin.org/articles/10.3389/fped.2019.00347/full -
Content of n-3 LC-PUFA in breast milk four months postpartum is associated with infancy blood pressure in boys and infancy blood lipid profile in girls
https://www.ncbi.nlm.nih.gov/pubmed/30678226 -
Osteopontin in human milk and infant formula affects infant plasma ostepontin concentrations
https://www.ncbi.nlm.nih.gov/pubmed/30636771 -
Preclinical Brown Norway rat models for the assessment of infant formulas in the prevention and tretament of cow's milk allergy
https://www.ncbi.nlm.nih.gov/pubmed/30759437 -
The Impact of Immune Interventions: A Systems Biology Strategy for Predicting Adverse and Beneficial Immune Effects.
https://www.frontiersin.org/articles/10.3389/fimmu.2019.00231/full -
Fecal microbiome and metabolome of infants fed bovine MFGM supplemented formula or standard formula with breast-fed infants as reference: a randomized controlled trial
https://www.ncbi.nlm.nih.gov/pubmed/31406230 -
Metabolic phenotype of breast-fed infants, and infants fed standard formula or bovine MFGM supplemented formula: a randomized controlled trial
https://www.ncbi.nlm.nih.gov/pubmed/30674917 -
Effects of milk fat globule membrane and its various components on neurologic development in a postnatal growth restriction rat model
https://www.ncbi.nlm.nih.gov/pubmed/31096073 -
The enduring effects of early-life stress on the microbiota-gut-brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend
https://www.ncbi.nlm.nih.gov/pubmed/31339598 -
Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs
https://www.ncbi.nlm.nih.gov/pubmed/31207876 -
Hydrolyzed formula with reduced protein contents supports adequate growth: A randomized controlled non-inferiority trial
https://www.ncbi.nlm.nih.gov/pubmed/29216020 -
Osteopontin in human milk and infant formula affects infant plasma ostepontin concentrations
https://www.ncbi.nlm.nih.gov/pubmed/30636771 -
Satiety Factors Oleoylethanolamide, Stearoylethanolamide, and Palmitoylethanolamide in Mother's Milk Are Strongly Associated with Infant Weight at Four Months of Age-Data from the Odense Child Cohort
https://www.ncbi.nlm.nih.gov/pubmed/30428553 -
Effect of bovine milk fat globule membranes as a complementary food on the serum metabolome and immune markers of 6-11-month-old Peruvian infants
https://www.ncbi.nlm.nih.gov/pubmed/31304256 -
Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes
https://www.ncbi.nlm.nih.gov/pubmed/30120403 -
The role of milk fat globule membranes in behavior and cognitive function using a suckling rat pup supplementation model
https://www.ncbi.nlm.nih.gov/pubmed/29909352 -
Milk Fat Globule Membrane Supplementation in Formula-fed Rat Pups Improves Reflex Development and May Alter Brain Lipid Composition
https://www.ncbi.nlm.nih.gov/pubmed/30323309 -
Early life diets with prebiotics and bioactive milk fractions attenuate the impact of stress on learned helplessness behaviours and alter gene expression within neural circuits important for stress resistance
https://www.ncbi.nlm.nih.gov/pubmed/27763700 -
Milk Fat Globule Membrane Inhibits NLRP3 Inflammasome Activation and Enhances Intestinal Barrier Function in a Rat Model of Short Bowel
https://www.ncbi.nlm.nih.gov/pubmed/30144105 -
Milk Fat Globule Membrane Attenuates High-Fat Diet-Induced Obesity by Inhibiting Adipogenesis and Increasing Uncoupling Protein 1 Expression in White Adipose Tissue of Mice
https://www.ncbi.nlm.nih.gov/pubmed/29522452 -
Mining Milk for Factors which Increase the adherence of Bifidobacterium longum subsp. Infantis to Intestinal Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306836/pdf/foods-07-00196.pdf -
Milk fat globule membrane supplementation modulates the gut microbiota and attenuates metabolic endotoxemia in high-fat diet-fed mice
https://www.sciencedirect.com/science/article/pii/S1756464618302548 -
Bioactive Whey Protein Concentrate and Lactose Stimulate Gut Function in Formula-fed Preterm Pigs
https://www.ncbi.nlm.nih.gov/pubmed/28753186 -
Effects of osteopontin-enriched formula on lymphocyte subsets in the first 6 months of life: a randomized controlled trial
https://www.ncbi.nlm.nih.gov/pubmed/28355198 -
Breastfeeding, infant formula, and introduction to complementary foods-comparing data obtined by questionnaires and helth visitors' reports to weekly short message service text messages
https://www.ncbi.nlm.nih.gov/pubmed/28832183 -
Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development
https://www.ncbi.nlm.nih.gov/pubmed/28349941 -
Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity
https://www.ncbi.nlm.nih.gov/pubmed/28119579 -
Oral Microbiota in Infants Fed a Formula Supplemented with Bovine Milk Fat Globule Membranes - A Randomized Controlled Trial
https://www.ncbi.nlm.nih.gov/pubmed/28099499 -
Growth, nutrition, and cytokine response of breast-fed infants and infants fed formula with added bovine osteopontin
https://www.ncbi.nlm.nih.gov/pubmed/26465791 -
Prebiotics and Bioactive Milk Fractions Affect Gut Development, Microbiota, and Neurotransmitter Expression in Piglets
https://www.ncbi.nlm.nih.gov/pubmed/27031373 -
Dietary Prebiotics, Milk Fat Globule Membrane, and Lactoferrin Affects Structural Neurodevelopment in the Young Piglet
https://www.ncbi.nlm.nih.gov/pubmed/26870719 -
Early life diet containing prebiotics and bioactive whey protein fractions increased dendritic spine density of rat hippocampal neurons
https://www.ncbi.nlm.nih.gov/pubmed/27603970 -
Hydrolyzed whey protein prevens the development of food allergy to ß-lactoglobulin in sensitized mice
https://www.ncbi.nlm.nih.gov/pubmed/26364716 -
Infections in infants fed formula supplemented with bovine milk fat globule membranes
https://www.ncbi.nlm.nih.gov/pubmed/25714582 -
Pre-clinical in vitro and in vivo safety evaluation of bovine whey derived osteopontin, Lacprodan® OPN-10
https://www.ncbi.nlm.nih.gov/pubmed/25072164 -
Suppression of tumor growth by orally administered osteopontin is accompanied by alterations in tumour blood vessels
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950862/ -
Bovine osteopontin modifies the intestinal transcriptome of formula-fed infant rhesus monkeys to be more similar to those that were breastfed
https://www.ncbi.nlm.nih.gov/pubmed/25320184 -
Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial.
https://www.ncbi.nlm.nih.gov/pubmed/24500150 -
Safety and tolerance evaluation of milk fat globule membrane-enriched infant formulas: a randomized controlled multicenter non-inferiority trial in healthy term infants
https://www.ncbi.nlm.nih.gov/pubmed/25452707 -
Cardiovascular risk markers until 12 mo of age in infants fed a formula supplemented with bovine milk fat globule membranes
https://www.ncbi.nlm.nih.gov/pubmed/25116230 -
Raw bovine milk improves gut responses to feeding relative to infant formula in preterm piglets
https://www.ncbi.nlm.nih.gov/pubmed/24157971 -
Early supplementation of phospholipids and gangliosides affects brain and cognitive development in neonatal piglets
https://www.ncbi.nlm.nih.gov/pubmed/25411030 -
Whey protein processing influences formula-induced gut maturation in preterm pigs
https://www.ncbi.nlm.nih.gov/pubmed/24047702 -
Alpha-Lactalbumin and Casein-Glycomacropeptide Do Not Affect Iron Absorption from Formula in Healthy Term Infants
https://www.ncbi.nlm.nih.gov/pubmed/22623383 -
Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising resistance in preterm pig
https://www.ncbi.nlm.nih.gov/pubmed/20723273 -
Efficacy of an MFGM-enriched complementary food in diarrhea, anemia, and micronutrient status in infants
https://www.ncbi.nlm.nih.gov/pubmed/21637131 -
Early feeding in infancy and atopic dermatitis - a prospective observational study
https://www.ncbi.nlm.nih.gov/pubmed/18270883 -
Formula Feeding Skews Immune Cell Composition toward Adaptive Immunity Compared to Breastfeeding
https://www.ncbi.nlm.nih.gov/pubmed/19734215 -
Effects of alpha-lactalbumin–enriched formula containing different concentrations of glycomacropeptide on infant nutrition
https://www.ncbi.nlm.nih.gov/pubmed/18400715 -
The effects of alpha-lactalbumin and glycomacropeptide on the association of CaCo-2 cells by enteropathogenic Escherichia coli, Salmonella typhimurium and Shigella flexneri
https://www.ncbi.nlm.nih.gov/pubmed/17130747 -
Effects of Bovine alpha-lactalbumin and Casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants
https://www.ncbi.nlm.nih.gov/pubmed/17130747 -
In vitro digestion of novel milk protein ingredients for use in infant formulas: Research on biological functions
https://www.sciencedirect.com/science/article/pii/S0924224404000068 -
Cow milk-specific humoral and cellular immune response in infants with high risk of atopy under feeding a whey hydrolysate infant formula
https://www.ncbi.nlm.nih.gov/pubmed/14520590 -
A two-stage continuous culture system to study the effect of supplemental alpha-lactalbumin and glycomacropeptide on mixed cultures of human gut bacteria challenged with enteropathogenic Escherichia and Salmonella serotype Typhimurium
https://www.ncbi.nlm.nih.gov/pubmed/12960649 -
rRNA Probes Used to Quantify the Effects of glycomacropeptide and alpha-lactalbumin supplementation on the predominat groups of intestinal bacteria of infant rhesus monkeys challenged with Enteropathogenic Escherichia coli
https://www.ncbi.nlm.nih.gov/pubmed/12960649 -
Glycomacropeptide and alpha-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys
https://www.ncbi.nlm.nih.gov/pubmed/12716681 -
Use of batch culture and a two-stage continuous culture system to study the effect of supplemental alpha-lactalbumin and glycomacropeptide on mixed population of human gut bacteria
https://www.ncbi.nlm.nih.gov/pubmed/19709257
Early life nutrition news
Press release
24/02/2021
