Allergy and comfort
Hydrolysed proteins are vital in formulas for infants diagnosed with an allergy to bovine milk proteins or identified as being in the allergy risk group. During the hydrolysis process, allergy-causing areas on a protein (epitopes) are destroyed or reduced to a minimum.
Animal studies have shown that partial hydrolysates can induce oral tolerance to intact proteins. Oral tolerance is the active non-response of the immune system to an allergen administered orally. If oral tolerance fails, food allergy occurs, which means oral tolerance is a critical process in the first few months of life.
Hydrolysates can benefit all formula fed infants as they are more easily digested. Ingestion of a protein hydrolysate, as opposed to the intact protein, is thought to facilitate protein digestion and absorption and increase plasma amino acid availability.
We have a broad range of hydrolysed casein and whey proteins which can be used for allergy treatment and prevention as well as comfort. These products are designed and tested for important quality descriptors such as antigenicity, molecular weight distribution and degree of hydrolysis to ensure a consistent quality to this sensitive consumer group.
There are two hydrolysate categories for use in infant nutrition:
- Extensive hydrolysates; almost all epitopes are destroyed. Ideal for allergic infants
- Partial hydrolysates; minimal number of epitopes are still present. Ideal for allergy prevention and comfort products
Peptigen®IF-3012, Peptigen®IF-3080, Peptigen®IF-3087 and Peptigen®IF-3090 have passed the ASA-test according to the Commission Directive 2006/141/EC Annex IV.
- Lacprodan® DI-3071: mildly hydrolysed whey protein suitable for infant comfort formulas. DH (6-10) and 80% protein concentrate approx. dry matter
- Lacprodan® DI-2021: casein protein hydrolysate containing high amounts of casein phospho peptides (CPP) DH (8) and 93% protein concentrate approx. dry matter
- Peptigen® IF-3087: Milk protein hydrolysate suitable in infant formulas with reduced allergen content. DH (18-20) and 78% protein concentrate approx. dry matter
- Peptigen® IF-3090: extensively hydrolysed whey protein suitable in infant formulas with reduced allergen content. DH (23-28) and 87% protein concentrate approx. dry matter
- Peptigen® IF-3012: Milk protein hydrolysate suitable in infant formulas with reduced allergen contents. DH (23-28) and 82% (as is) protein concentrate approx. dry matter
- Peptigen® IF-3080: Extensively hydrolysed whey protein suitable in infant formulas with reduced allergen content. DH (23-29) and 84% protein concentrate approx. dry matter
Nentwich et al. 2003. Klin Padiatr. 215: 275-279, Nentwich et al. 2009. Klin Padiatr. 221: 78-82.
Using infant formulas is second to breastfeeding, a fact supported by WHO. This information is for professional use only.